Biochem. 231(20):359-65 [1995], H. Iwahana et al., Multiple fluorescence-based PCR-SSCP analysis using internal fluorescent labeling of PCR products, Biotechniques 21(30:510-14, 516-19 [1996]). [0134] The label can also be an enzyme, such as horseradish peroxidase (HRP), glucose oxidase, ??-galactosidase, and the like.