Over-the-Counter Medication ??? It is recommended to use pain relievers for joint pain, such as Acetaminophen (Tylenol) and Nonsteroidal anti-inflammatory drugs, also known as NSAIDS), such as Ibuprofen (Advil), Aspirin (Bayer, Anacin) and Naproxen (Naprosyn or Aleve) and read all labels and instructions extremely carefully before taking them.