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  • For example, other known risk factors for RA, such as the shared epitope of HLA-DRB1, and smoking, may, in comparison with early menopause, be more specifically associated with a severe phenotype of RA [32,33].A recent study [12] suggested that OC use is associated with mild RA and demonstrated a reduction of disability, measured by HAQ over time, in former OC users, compared with nonusers.
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