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  • If additional analgesics are needed for breakthrough pain within the 6-hour dosing interval, acetaminophen or an acetaminophen/opioid combination drug can be safely given in conjunction with NSAIDs like ketorolac.17-19,22,23 According to the package insert, other NSAIDs including preparations containing ibuprofen or aspirin should not be administered concurrently with any formulation of ketorolac
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