Clinical Significance Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE.LOINC??' Code(s) The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics.