Back to Top brendabooVeteran Member Date Joined Mar 2014Total Posts : 755 Posted 2/28/2015 7:34 AM (GMT -6) Benadryl gives me the complete opposite effect, I get antsy, can not sleep and feel weird in the head.Before my son would go under anesthetic they would give him benadryl to help the effectiveness of the anesthesia and just in case there was an allergic reaction, they found out also with him t