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  • Ubiquitin immunohistochemistry has revealed enrichment in conjugates in senile plaques, lysosomes, endosomes, and a variety of inclusion bodies and degenerative fibers in many neurodegenerative diseases such as Alzheimer's (AD), Parkinson's and Lewy body diseases, amyotrophic lateral sclerosis (ALS) and Creutzfeld???Jakob disease (CJD) (reviewed in Mayer et al., 1996).
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