| http://www.w3.org/ns/prov#value | - Unlike other PIs, epoxyketones show potent selectivity to the proteasome, without inhibitory effects on other proteases such as calpain, trypsin, papain, chymotrypsin and cathepsins [31], due to the fact that epoxyketone moiety can form a morpholino adduct with the active site amino terminal Thr of the ??5 subunit [32].
|
