| http://www.w3.org/ns/prov#value | - For instance, many cytokines have been shown to regulate the expression of RANK and RANKL on osteoclast and osteoblasts respectively, or modulate the intracellular signalling mediated by RANK. In general, pro-inflammatory cytokines, such as IL-1, TNF-{alpha}, and IL-6, appear to act synergistically on osteoclastogenesis and promote osteoclast function.157-162 Table 1 summarises the effects of the
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