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  • For the first time we demonstrate that mature miR99a, let-7c, miR-125b-2, miR-155 and miR- 802, which are encoded by genes harbored on Hsa21, are over-expressed in human fetal hippocampus and heart samples from individuals with DS. As previously described, the end result of miRNA-mediated gene regulation is a reduction in the total amount of target protein that is produced [8???10], we speculate t
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  • pubmedcentralcanada.ca