| http://www.w3.org/ns/prov#value | - Costimulation is required not only for the early activation of T cells, but also for the later maintenance of their post-activation effector capacity, referred to as ???effector costimulation.??? In an effort to maintain therapeutic T cells in a fully activated state, activating cytokines, such as IL-2, have been administered systemically to patients receiving therapeutic T cells, albeit with IL-2
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