| http://www.w3.org/ns/prov#value | - In response to ligand stimulation from cytokines or from growth factors such as the insulin-like growth factor-I (IGF-I) and the epidermal growth factor (EGF) family, receptor tyrosine kinases are phosphorylated, an event which subsequently activates phosphatidylinositol 3-kinase (PI3K) signaling and stimulates the Akt axis as well as other downstream signaling pathways [1].
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