| http://www.w3.org/ns/prov#value | - During the initial stages of osteosarcoma invasion, growth factors such as TGF-?? are released from the degraded bone matrix and act on osteosarcoma cells, stimulating the release of PTHrP, interleukin-6 (IL-6) and interleukin-11 (IL-11) [114, 115].
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