| http://www.w3.org/ns/prov#value | - Prior to fractionation, e.g., contacting the sample or portions of the sample with a plurality of protein-binding molecules, such as small epitope antibodies or small epitope aptamers, the sample may be treated with one or more agents capable of denaturing and/or solubilizing proteins, such as detergents (ionic and non-ionic), chaotropes and/or reducing agents.
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