| http://www.w3.org/ns/prov#value | - OnabotulinumtoxinA (Botox), approved by the U.S. Food and Drug Administration (FDA) for cosmetic use in 2002, and the first hyaluronic acid-based dermal filler (Restylane), approved by the FDA in 2003, provided nonsurgical alternatives to rhytidectomy, forehead lifts, cheek implants, and other surgical procedures that target the effects of aging.
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