| http://www.w3.org/ns/prov#value | - It is proposed that cytokines such as TNF-?? that are produced systemically during sepsis activate cerebral microglia which, in turn, release inflammatory mediators within the CNS. These inflammatory mediators cause aberrant neuronal function and, thereby, delirium and SAE [49].Deficits in cholinergic function have been postulated to cause delirium and cognitive decline [51].
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