| http://www.w3.org/ns/prov#value | - Two PD-1 ligands have been described (PD-L1 and PD-L2), and their expression is regulated by the inflammatory environment, cytokines such as TNF-??, type 1 and 2 interferons, IL-2, IL-7, and IL-15 [59].The co-stimulatory pathways consisting of the PD-1 receptor and its ligands deliver inhibitory signals that regulate the balance among T-cell activation, tolerance, and immune-mediated tissue damage
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