| http://www.w3.org/ns/prov#value | - wherein FR1,CDR1H,FR2,CDR2H,FR3,CDR3H,FR4,FR.sub.6,CDR1L,FR7,CDR2L, FR8,CDR3L and FR9 have the meanings as mentioned before and Sp is a peptide spacer consisting of about 10 to 30, e.g. around 15, amino acids; and wherein the heavy chain or the light chain variable domain is further connected to an effector molecule, e.g. an enzyme, such as phosphatase, particularly alkaline phosphatase, or a toxi
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