| http://www.w3.org/ns/prov#value | - In some embodiments, the FR3 has a sequence including two or more amino acid substitutions as compared to the FR3 sequence of a provided reference antibody. [0113] In some embodiments, a provided VH framework region 4 (FR4) shows at least 80%, at least 85%, at least 90%, at least 95%, or at least 99% percen
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