| http://www.w3.org/ns/prov#value | - In turn, the cytokines may activate additional cortisol synthesis in the skin as it is well established in the immune response to injury, proinflammatory cytokines such as TNF-??, Il-1 and Il-6, act on the hypothalmic, pituitary, or adrenal component of the HPA axis causing an increased release of cortisol.
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