| http://www.w3.org/ns/prov#value | - Starczynowski et al showed that miR-146a is down-regulated in clinical samples of 5q- syndrome and stable knockdown of miR-145 and miR-146a concurrently in mouse HSCs recapitulates many features of human 5q- syndrome, a subtype of myelodysplastic syndrome.34,47 In addition, miR-146a has been found to be extensively dysregulated in autoimmune diseases, including lupus and rheumatoid arthritis.33,46
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