| http://www.w3.org/ns/prov#value | - Other innate immune cells such as monocytes have also been implicated in the pathogenesis of PBC since their pro-inflammatory activity is greatly enhanced in PBC. Functionally, monocytes become activated by pathogen-associated patterns through TLR to release pro-inflammatory cytokines, including IL-1, IL-6, IL-18, IL-12, and TNF-?? that can amplify adaptive T cell mediated immune responses against
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