| http://www.w3.org/ns/prov#value | - It is understood by one skilled in the art that certain reactions, such as reactions employing sterically hindered nucleophiles, may require extended reaction times outside the typical period of 3 to 24 hours. [0148] Reaction Scheme 1A depicts the preparation of a nocathiacin derivative within Formula I. The nocathiacin starting material is treated with an appropriate amine or thiol of general for
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