| http://www.w3.org/ns/prov#value | - Hydroxyurea and other pharmacologic agents have been identified that promote the production of HbF, and hydroxyurea has been shown in randomized clinical trials to decrease the frequency of painful crises in human SCD.1Recent human genetic studies have identified the gene encoding BCL11A as a locus that is important for control of HbF synthesis.2 Subsequent studies in mice and in human erythroid c
|
