| http://www.w3.org/ns/prov#value | - Myc, HIF or both.Keywords: HIF, c-Myc, targeted therapy, tumor microenvironmentIntroductionThe basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor c-Myc regulates the expression of 10???15% of all genes of the genome.1???5 In addition, it directly regulates DNA replication.6 Deregulation of c-Myc occurs in ~30% of human cancers including breast, colon, cervical, small-cell lung ca
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