| http://www.w3.org/ns/prov#value | - In the instance of TKI monotherapy, studies have shown that diarrhoea is dose dependent rather than associated with pharmacokinetics [17, 18], suggesting that the toxicity is predominantly caused by luminal exposure to the drug.EGFR is expressed by cells of epithelial origin, including the skin and gastrointestinal tract, so it is not surprising that toxicities affect these systems.
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