| http://www.w3.org/ns/prov#value | - Following their first report of three such auxotroph mutants in 1941, Beadle and Tatum used this method to create series of related mutants and determined the order in which amino acids and some other metabolites were synthesized in several metabolic pathways.[7] The obvious inference from these experiments was that each gene mutation affects the activity of a single enzyme.
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