| http://www.w3.org/ns/prov#value | - mall (~2-fold BiP induction) and required prolonged (48 h) stimulation.85 This is not surprising given that cytokines and other exogenous stimuli can upregulate hundreds of proteins, including membrane bound and secreted proteins that are produced in the ER. This low level UPR is likely part of the normal physiologic response that enables cells to handle the increased load.
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