| http://www.w3.org/ns/prov#value | - Such a nicotine hapten is then coupled to core particles of present invention with an activating reagent e.g. HATU. In one embodiment, the precursor of the conjugates is synthesized by acylating racemic nornicotine with succinic anhydride in methylene chloride in the presence of two equivalents of diisopropylethylamine.
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