| http://www.w3.org/ns/prov#value | - During the active release, HMGB1 undergoes different post-translational modifications, including hyper-acetylation, phosphorylation and ADP-ribosylation that facilitate HMGB1 dissociation from chromatin and, thus, its translocation to the cytoplasm where it is packaged into specialized secretory lisosomes [15,16,17].This ???non-classical??? active release mechanism is Ca2+-dependent [18].
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