| http://www.w3.org/ns/prov#value | - Liver kinase B1 (LKB1) and AMP-activated protein kinase (AMPK) are critical regulators of mTORC1.28 Most functions of mTORC1 are inhibited by rapamycin, a triene macrolide antibiotic synthesized by Streptomyces hygroscopicus.27mTORC1 has to be regarded as a pivotal convergence point in cell signaling, because it integrates many intra- and extracellular signals such as growth factors (insulin, IGF-
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