| http://www.w3.org/ns/prov#value | - Because GM-CSF is a key factor for maintaining the differentiation and proliferation of macrophages, dysfunction of AMs due to the neutralization of GM-CSF bioactivity by an autoantibody is a plausible explanation for the pathogenesis of human I-PAP. In fact, AMs from patients with active acquired PAP are known to be functionally impaired 1415.
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