• Microtubular disruption occurs at very low VCR concentrations and appears to be significantly influenced by the duration of exposure in vitro.8, 31 Clinically, however, the incidence of toxicity, particularly neurotoxicity, is related to a complex interplay among patient age, body weight and composition, VCR dose, schedule, and pharmacokinetics.Previous reports of the use of high-dose VCR administ