| http://www.w3.org/ns/prov#value | - Single mismatches, or base-substitutions, near the site of cleavage can completely eliminate catalytic activity of a ribozyme. [0085] The enzymatic nucleic acid molecule that cleave the specified sites in EGFR-specific RNAs represent a novel therapeutic approach to treat a variety of cancers, including but not limited to breast, lung, prostate, colorectal, brain, esophageal, bladder, pancreatic, c
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