| http://www.w3.org/ns/prov#value | - In one aspect, the invention provides methods comprising expressing in a host cell (for e.g., a prokaryotic cell such as E. coli) a variant immunoglobulin heavy chain, said variant immunoglobulin heavy chain having a reduced ability to form a disulfide linkage such that amount of self aggregation (for example, in the periplasm) of the variant immunoglobulin heavy chain is less than the amount of s
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