| http://www.w3.org/ns/prov#value | - In both cases, the ??CH1 gene may be functionally silenced by class switch recombination.The L-chain deficient mouse used in the method may have a nucleic acid construct integrated in the endogenous mouse genome, in which the nucleic acid construct comprises:(i) non-murine vertebrate (for example, human) heavy chain V, D, J and C genes, for example in non-murine vertebrate (for example, human) or
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