| http://www.w3.org/ns/prov#value | - In RA, major signs and symptoms such as pain,inflammation, and stiffness vary as a function of the timeof day, usually with the greatest severity of symptomsoccurring in the morning hours.In RA, pain, inflammation, and stiffness arepreceded by elevated levels of IL-6, TNF, and otherproinflammatory cytokines (23???29), and a causal???notonly a temporal???relationship has been suggested forthe follo
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