| http://www.w3.org/ns/prov#value | - In another aspect, the invention provides a method of treating or prophylaxis of a disease or condition in a mammal in need thereof where the disease or condition is a PDE4-mediated disease or condition or a disease or condition in which PDE4 modulation provides a therapeutic benefit, by administering to the mammal a therapeutically effective amount of a compound of Formula I, Ia, Ib, Ic, Id, or I
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