| http://www.w3.org/ns/prov#value | - Likewise, SPARC augments the inhibitory functions of TGF??1 in epithelial cells by stimulating smad2/3 phosphorylation (Schiemann et al. 2003).Considering that growth factors such as bFGF, PDGF, VEGF and TGF?? are important contributors to tumor progression, angiogenesis and metastasis, it is clear that the interaction of SPARC with these signaling pathways influences its ability to dictate many a
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