| http://www.w3.org/ns/prov#value | - Ongoing research is searching for mediators and cytokines such as the TGF-??1 and the granulocyte macrophage colony growth factor (GM-CSF), which may be released by local inflammatory cells to activate those fibroblasts.41,42 Nitric oxide (NO) is a key mediator for the endothelium-derived relaxing factor (EDRF) that is responsible for relaxing vascular smooth muscle.43 NO is elevated in asthmatic
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