| http://www.w3.org/ns/prov#value | - In the fourth quarter and full-year 2012, other net charges primarily includes severance, facilities, asset impairment and other restructuring charges associated with the closure of the South San Francisco facility and related reduction in headcount, following the announcement during the third quarter of 2012 of the separation of the Prothena business and cessation of the remaining early stage res
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