| http://www.w3.org/ns/prov#value | - In guinea-pigs however AP shortening was observed at lower concentrations such as around 5 ??M. In a second paper the same authors (Rodrigo et al., 1999) also demonstrated that PUFA at the same concentrations inhibit RyR. The inhibition of calcium current and the RyR and the shortening of the AP produce marked reduction in calcium transient amplitude and cell shortening.
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