| http://www.w3.org/ns/prov#value | - Secondly, certain mutant forms of heparinase I, viz., S377A (where the amino acid serine 377 in wild type heparinase I is mutated to alanine), have been developed that result in a heparinase I enzyme that is calcium-independent, i.e., the enzyme is as active in the absence of calcium as it is in the presence of calcium.
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