| http://www.w3.org/ns/prov#value | - They include increased generation or impaired clearance of self-antigens, particularly nucleic acids, and capacity to activate autoantigen-specific immune response, including T cell and B cell activation and differentiation to plasma cells.6,27 Most relevant to this review are a growing number of lupus-associated genetic variants, both common and rare, that impact type I IFN prod
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