| http://www.w3.org/ns/prov#value | - Thus, different reaction conditions (e.g., different pHs or different temperatures) can result in the attachment of a hydrophilic polymer such as PEG to different locations on the insulin (e.g., internal lysines versus the N-terminus).In some embodiments, insulin is reacted with a reactive hydrophilic polymer by contacting insulin with a hydrophilic polymer in an organic solvent.
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