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  • Proinflammatory cytokines, such as TNF?? and IL-1b, secreted by cancer cells, induce TF expression from monocytes and endothelial cells, reduce the expression of thrombomodulin, a key factor in the protein C pathway [9], suppress the fibrinolytic activity of endothelium and increase the endothelial production of e-selectin and von Willebrand factor (vWF) [11].The production of vascular endothelial
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  • pubmedcentralcanada.ca