| http://www.w3.org/ns/prov#value | - rom 350,000 cases in 1988 to 223 cases in 2012. [112, 113] Animal research has also contributed to major advances in understanding and treating conditions such as breast cancer, brain injury, childhood leukemia, cystic fibrosis, malaria, multiple sclerosis, tuberculosis, and many others, and was instrumental in the development of pacemakers, cardiac valve substitutes, and anesthetics. [10, 11, 12,
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