| http://www.w3.org/ns/prov#value | - From the above description of a typical synthetic procedure, at least the following limitations are apparent: (1) the whole process, especially liquid-liquid extraction (LLE) and washing, is tedious and difficult to automate; (2) reaction, work-up and chromatography sequences are time consuming; (3) catalysts are often not easily reused; and (4) use of large amounts of solvents and waste productio
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