| http://www.w3.org/ns/prov#value | - response to many stimuli such as Gprotein-coupled receptor agonists, receptor tyrosine kinase agonists, cytokines, reactiveoxygen species, and stretch.7 These various stimuli initiate MAP3Ks, which thenphosphorylate and activate the dual-specificity kinases MEK1 and MEK2 (MAP2Ks) thatserve as dedicated kinases for ERK1/2 phosphorylation and activation.11Interestingly, while transgenic mice over-ex
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