| http://www.w3.org/ns/prov#value | - ruption of CCN3 in mice causes abnormal development of bones, heart and skeletal muscles (Lin et al., 2005), the same tissues that are altered in Tsk mice.In conclusion, this report defines an important and novel function of CCN3 in extracellular homeostasis that is relevant to CTDs, including SSc and MFS. Further understanding of the interaction of CCN3 with TGF-?? and Wnt should provide new insi
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